Focus on Flavonoids Extract
CAS No.: 520-27-4
EIENCS: 208-289-7
Molecular Formula: C28H32O15
Molecular Weight: 608.545
Specification: EP, BP, USP, 90:10, Micronized
Diosmin is a semisynthetic flavonoid molecule derived from citrus d(modified hesperidin). Diosmin is used for treating various disorders of blood vessels including hemorrhoids, varicose veins, poor circulation in the leg(venous stasis), and bleeding(hemorrhage) in the eye or gums. It is also used to treat swelling of the arms(lymphedema) following breast cancer surgery, and to protect against liver toxicity. It is often taken in combination with hesperidin. Diosmin is currently a prescription medication in some European countries, and is sold as a nutritional supplement in the US.
Product Name | Diosmin |
---|---|
Botanical Source | Citrus Aurantium L. |
Used Part | Immature fruit |
Code | BPBE-610-A |
Specification | EP8.3 Micronized |
Appearance | Greyish-yellow or light yellow, hygroscopic powder |
Solubility | Practically insoluble in water, soluble in dimethyl sulfoxide, practically insoluble in ethanol (96%), it dissolves in dilute solution of alkali hydroxides |
Identification | A)IR: Complies diosmin CRS; B)HPLC: Complies to the reference solution |
Iodine | ≤0.1% |
Related Substances | |
Impurity A(Acetoisovanillone) | ≤0.5% |
Impurity B(Hesperidin) | ≤4.0% |
Impurity C(Isorhoifolin) | ≤3.0% |
Impurity D(6-iododiosmin) | ≤0.6% |
Impurity E (Linarin) | ≤3.0% |
Impurity F(Diosmetin) | ≤2.0% |
Unspecified Impurities(each) | ≤0.4% |
Total Impurities | ≤8.5% |
Heavy Metals | ≤20ppm |
Water | ≤6.0% |
Sulphated Ash | ≤0.2% |
Particle Size | NLT90% below 5 microns |
Assay(HPLC, Anhydrous substance) | 90.0%~102.0% |
Residual Solvents | |
Methanol | ≤3000ppm |
Ethanol | ≤5000ppm |
Pyridine | ≤200ppm |
Total Plate Count | ≤1000cfu/g |
-Yeast & Mold | ≤100cfu/g |
-E.Coli | Negative |
-Salmonella | Negative |
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